Nitrocefin CAS: 41906-86-9

Basic information

Nitrocefin

Synonym： 3-(2,4-DINITROSTYRYL)-(6R,7R)-7-(2-THIENYLACETAMIDO)-CEPH-3-EM-4CARBOXYLICACID,E-ISOMER;(6R)-3-[(E)-2-(2,4-Dinitrophenyl)ethenyl]-8-oxo-7α-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid;Nitrocefin(>90%);(6R,7R)-3-[(E)-2-(2,4-dinitrophenyl)ethenyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amiChemicalbookno]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid;NITROCEFIN;3-[(E)-2-(2,4-Dinitrophenyl)vinyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid;Nitrocefin(>5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[(1E)-2-(2,4-dinitrophenyl)ethenyl]-8-oxo-7-[(2-thienylacetyl)amino]-,(6R,7R)-

CAS： 41906-86-9

Molecular formula： C21H16N4O8S2

Molecular weight：516.5

Chemical Properties

Utilize

Cefnitrothiophene is a widely used chromogenic cephalosporin substrate used for detecting the presence of bacteria β- Lactam enzyme. Also known as 6- (2-nitrophenyl-3 ', 5' - diphenylcarbamoyl-4 methyl-2-oxo-2H-pyran-3 carboxylic acid, it is a chromogenic cephalosporin substrate used for detection β- Lactam activity in bacteria.
Cefnitrothiophene is widely used as a diagnostic tool in microbiology laboratories to detect the presence of clinically isolated bacteria β- Lactam enzyme, which can endow β- Resistance to lactam antibiotics such as penicillin and cephalosporin.
In the β- In the presence of lactam, cefnidazole is bright yellow, making it a useful, cost-effective screening tool for rapid identification of antibiotic resistant bacteria. In addition, it is effective for detecting β- Lactam enzyme has high sensitivity and specificity, making it a valuable tool for monitoring emerging antibiotic resistance in clinical environment.

Characteristics of Cefnitrothiophene
1. High sensitivity: Cefnidazole against β- Lactam enzyme activity is highly sensitive, which means that it can even detect micro enzymes that may not be detected by other tests.
2. Specificity: Cefnidazole is effective against β- The specificity of lactam enzyme means that it will not react with other enzymes or compounds that may exist in bacterial samples.
3. Speed: Cefnidazole produces visible color changes within a few minutes after detection, making it a fast and effective identification method β- Methods of lactam enzyme activity.
4. Cost-effective: Cefnidazole is relatively inexpensive and widely used, making it a cost-effective choice for laboratories.
5. Multifunctionality: Cefnidazole can be used to detect various bacteria β- Lactam enzyme activity, including those that may affect β- Lactam antibiotic resistant bacteria.
Overall, Cefnitrothiophene is used to detect bacteria β- Lactam enzyme activity is an important tool, which has many advantages compared with other detection methods.